Publikationen PD Dr. Hermanns


[1]       Chen, W., Thielmann, I., Gupta, S., Subramanian, H., Stegner, D., van Kruchten, R., Dietrich, A., Gambaryan, S., Heemskerk, J.W.M., Hermanns, H.M., Nieswandt, B., Braun, A. (2014) Orai1-induced store-operated calcium entry enhances phospholipase activity and modulates TRPC6 function in murine platelets. J Thromb Haemost, accepted for publication

[2]       Duppatla, V., Gjorgjevikj, M., Schmitz, W., Hermanns, H.M., Schäfer, C.M., Kottmair, M., Müller, T., Sebald, W. (2013) IL-4 Analogues with Site-Specific Chemical Modification at Position 121 Inhibit IL-4 and IL-13 Biological Activities. Bioconjug Chem, accepted for publication

[3]       Dütting, S., Vögtle, T., Morowski, M., Schießl, S., Schäfer, C.M., Watson, S.K., Hughes, C.E., Ackermann, J.A., Radtke, D., Hermanns, H.M., Watson, S., Nitschke, L., Nieswandt, B. (2013) Grb2 Contributes to (hem)ITAM-Mediated Signaling in Platelets. Circ Res, accepted for publication doi: 10.1161/CIRCRESAHA.114.302670

[4]       Bonito, N.A., Drechsler, J., Stoecker, S., Carmo, C.R., Seckl, M.J., Hermanns, H.M., Costa-Pereira, A.P. (2013) Control of gp130 expression by the mitogen-activated protein kinase ERK2. Oncogene, accepted for publication doi: 10.1038/onc.2013.159

[5]       Kober, F.X., Koelmel, W., Kuper, J., Drechsler, J., Mais, C., Hermanns, H.M., Schindelin, H. (2013) The crystal structure of the protein-disulfide isomerase family member ERp27 provides insights into its substrate binding capabilities J. Biol. Chem. 288, 2029-2039

[6]       Gupta, S., Braun, A., Morowski, M., Premsler, T., Bender, M., Nagy, Z., Sickmann, A., Hermanns, H.M., Bösl, M., Nieswandt, B. (2012) CLP36 is a negative regulator of GPVI signaling in platelets. Circ Res. 111, 1410-20

[7]       Drechsler, J., Grötzinger, J., Hermanns, H.M. (2012) Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptor. PLoS One 7 (8), e43155

[8]       Radtke, S., Wüller, S., Yang, X., Lippok, B.E., Mütze, B., Mais, C., Schmitz-Van de Leur, H., Bode, J.G., Gaestel, M., Heinrich, P.C., Behrmann, I., Schaper, F.*, Hermanns, H.M.* (2010) Cross-regulation of cytokine signalling: Pro-inflammatory cytokines restrict IL-6 signaling through receptor internalisation and degradation. J. Cell Sci. 123, 947-959 (*contributed equally)

[9]       Hintzen, C*, Quaiser, S.*, Pap, T., Heinrich, P.C., Hermanns, H.M. (2009) Induction of CCL13 expression in synovial fibroblasts highlights a significant role of oncostatin M in rheumatoid arthritis. Arthritis & Rheum. 60, 1932-1943 (*contributed equally)

[10]     Heise, R., Neis, M.M., Marquardt, Y., Joussen, S., Heinrich, P.C., Merk, H.F., Hermanns, H.M., Baron, J.M. (2009) IL-31 receptor alpha expression in epidermal keratinocytes is modulated by cell differentiation and interferon gamma. J. Invest. Dermatol., 129, 240-243

[11]     Hintzen, C., Haan, C., Tuckermann, J., Heinrich, P.C., Hermanns, H.M. (2008) Oncostatin M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression J. Immunol., 181, 7341-7349

[12]     Hintzen, C., Evers, C., Lippok, B.E., Volkmer, R., Heinrich, P.C., Radtke, S.*, Hermanns, H.M.* (2008) Box 2 region of the Oncostatin M receptor determines specificity for recruitment of Janus kinases and STAT5 activation J. Biol. Chem., 283,19465-77  (*contributed equally)

[13]     Neis, M.M.*, Peters, B.*, Dreuw, A.*, Wenzel, J., Bieber, T., Mauch, C., Krieg, T., Stanzel, S., Heinrich, P.C., Merk, H.F., Bosio, A., Baron, J.M., Hermanns, H.M. (2006) Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. J. Allergy Clin. Immunol, 118, 930-937 (*contributed equally)

[14]     Stross, C., Radtke, S., Clahsen, T., Gerlach, C., Volkmer-Engert, R., Schaper, F., Heinrich, P.C., Hermanns, H.M. (2006) Oncostatin M receptor-mediated signal transduction is negatively regulated by suppressor of cytokine signalling (SOCS) 3 through a receptor tyrosine-independent mechanism. J. Biol. Chem. 281, 8458-8468

[15]     Böing, I.*, Stross, C.*, Radtke, S.*, Lippok, B.E.*, Heinrich, P.C., Hermanns, H.M. (2006) Oncostatin M-induced activation of stress-activated MAPK depends on tyrosine 861 in the OSM receptor and requires Jak1 but not Src kinases. Cell. Signal. 18, 50-61 (*contributed equally)

[16]     Costa-Pereira, A.P. *, Hermanns, H.M.*, Is’harc, H.*, Williams, T.M.*, Watling, D.*, Arulampalam, V., Newman, S.J., Heinrich, P.C., Kerr, I.M. (2005) Signaling through a Mutant IFN-{gamma} Receptor. J. Immunol. 175, 5958-5965  (*contributed equally)

[17]     Radtke, S.*, Haan, S.*, Jörissen, A.*, Hermanns, H.M., Diefenbach, S., Smyczek, T., Schmitz-Van de Leur, H., Heinrich, P.C., Behrmann, I.*, Haan, C.* (2005) The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and upregulation of receptor surface expression. J. Biol. Chem. 280, 25760-8  (*contributed equally)

[18]     Clahsen, T., Lehmann, U., Stross, C., Hermanns, H.M., Volkmer-Engert, R., Schneider-Mergener, J., Heinrich, P.C., Schaper, F. (2005) The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor mediates negative regulation of LIF signalling. Cell. Signal. 17, 559-569

[19]     Dreuw, A.*, Hermanns, H.M.*, Heise, R., Joussen, S., Rodríguez, F., Marquardt, Y., Jugert, F., Merk, H.F., Heinrich, P.C., Baron, J.M. (2005) Interleukin-6-type cytokines upregulate expression of multidrug resistance-associated proteins in NHEK and dermal fibroblasts. J. Invest. Dermatol., 124, 28-37  (contributed equally)

[20]     Dreuw, A., Radtke, S., Pflanz, S., Lippok, B.E., Heinrich, P.C., Hermanns, H.M. (2004) Characterization of the signaling capacities of the novel gp130-like cytokine receptor. J. Biol. Chem. 279, 36112-36120

[21]     Greiser, J.S., Stross, C., Heinrich, P.C., Behrmann, I., Hermanns, H.M. (2002) Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling J. Biol. Chem. 277, 26959-26965

[22]     Radtke, S., Hermanns, H.M., Haan, C., Schmitz-Van de Leur, H., Gascan, H., Heinrich, P.C., Behrmann, I. (2002) Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression. J. Biol. Chem. 277, 11297-11305

[23]     Haan, C., Is’harc, H., Hermanns, H.M., Schmitz-Van De Leur, H., Kerr, I.M., Heinrich, P.C., Grötzinger, J., Behrmann, I. (2001) Mapping of a region within the N-terminus of Jak1 involved in cytokine receptor interaction. J. Biol. Chem. 276, 37451-37458

[24]     Hermanns, H.M., Radtke, S., Schaper, F., Heinrich, P. C., Behrmann, I. (2000) Non-redundant signal transduction of interleukin-6-type cytokines: The adapter protein Shc is specifically recruited to the oncostatin M receptor. J. Biol. Chem. 275, 40742-40748

[25]     Anhuf, D., Weissenbach, M., Schmitz, J., Sobota, R., Hermanns, H.M., Radtke, S., Linnemann, S., Behrmann, I., Heinrich, P.C., Schaper, F. (2000) Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation. J. Immunol. 165, 2535-2543

[26]     Haan, C., Hermanns, H.M., Heinrich, P.C., Behrmann, I. (2000) A single amino acid substitution (Trp(666)–>Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction. Biochem. J. 349, 261-266

[27]     Hermanns, H.M.*, Radtke, S.*, Haan, C., Schmitz-Van de Leur, H., Tavernier, J., Heinrich, P. C., Behrmann, I. (1999) Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130. J. Immunol. 163, 6651-6658     (*contributed equally)

[28]     Behrmann, I., Janzen, C., Gerhartz, C., Schmitz-Van de Leur, H., Hermanns, H., Heesel, B., Graeve, L., Horn, F., Tavernier, J., Heinrich, P.C. (1997) A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation. J. Biol. Chem. 272, 5269-5274



[Ü1]    Garbers, C., Hermanns, H.M., Schaper, F., Müller-Newen, G., Grötzinger, J., Rose-John, S., Scheller, J. (2012) Plasticity and cross-talk of interleukin-6-type cytokines. Cytokine Growth Factor Rev. 23, 85-97

[Ü2]    Hermanns, H.M., Müller-Newen, G., Heinrich, P.C., Haan, S. (2005) Bow to your partner for signaling. Nat. Struct. Mol. Biol. 12, 476-478

[Ü3]    Heinrich, P.C.*, Behrmann, I.,* Haan, S.*, Hermanns, H.M.*, Müller-Newen, G.*, Schaper, F* (2003) Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem. J. 374, 1-20 (*all authors contributed equally)



[B1]     Heinrich, P.C., Behrmann I., Haan, S., Hermanns, H.M., Müller-Newen, G., Schaper, F. (2003) Structural bases of receptor-JAK-STAT interactions in: Signal Transducers and Activators of Transcription (STATs): Activation and Biology, 43-53, Editors: P. B. Sehgal, D. E. Levy and T. Hirano, Kluwer Academic Publishers, Dordrecht ;NL

[B2]     Heinrich, P.C., Barthel, A., Behrmann, I., Feld, F., Grötzinger, J., Haan, C., Hermanns, H.M. et al. (2002) Regulation of Interleukin-6-type cytokine signalling. in: Cytokines in Liver Injury and Repair, 221-237, Editors: A. Gressner, S. Matern, P.C. Heinrich, Kluwer Academic Publishers, Dordrecht, NL

[B3]     Heinrich, P.C., Behrmann, I., Bode, J.G., Gatsios, P., Graeve, L., Hermanns, H.M. et al. (2000) Termination and modulation of interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway in: Cytokines and Cell Homeostasis in the Gastrointestinal Tract, 206-228, Editors: T. Andus, G. Rogler, K. Schlottmann, E. Frick, G. Adler, M. Zeitz, W. Schmiegel, J. Schölmerich , Kluwer Academic Publishers, Dordrecht, NL



[LB1]   Müller-Newen, G., Heinrich, P.C., Hermanns, H.M., Schaper, F. (2014) Prinzipien extrazellulärer Kommunikation (Kapitel 33) in: Löffler/Petrides Biochemie und Pathobiochemie, Springer Lehrbuch, 9. Auflage, Editors: P.C. Heinrich, M. Müller, L. Graeve, Springer Verlag GmbH, Berlin

[LB2]   Heinrich, P.C., Haan, S., Hermanns, H.M., Müller-Newen, G., Schaper, F. (2014) Mediatoren (Kapitel 34) in: Löffler/Petrides Biochemie und Pathobiochemie, Springer Lehrbuch, 9. Auflage, Editors: P.C. Heinrich, M. Müller, L. Graeve, Springer Verlag GmbH, Berlin

[LB3]   Heinrich, P.C., Haan, S., Hermanns, H.M., Müller-Newen, G., Schaper, F. (2014) Rezeptoren und ihre Signaltransduktion (Kapitel 35) in: Löffler/Petrides Biochemie und Pathobiochemie, Springer Lehrbuch, 9. Auflage, Editors: P.C. Heinrich, M. Müller, L. Graeve, Springer Verlag GmbH, Berlin

[LB4]   Heinrich, P.C., Haan, S., Hermanns, H.M., Löffler, G., Müller-Newen, G., Schaper F. (2007) Kommunikation zwischen Zellen: Extrazelluläre Signalmoleküle, Rezeptoren und Signaltransduktion (Kapitel 25) in: Biochemie und Pathobiochemie, Springer Lehrbuch, 8. Auflage, S. 755-808, Editors: G. Löffler, P.E. Petrides, P.C. Heinrich, Springer Verlag GmbH, Berlin